2017

Microb Cell Fact. 2017 Jul 27;16(1):131. doi: 10.1186/s12934-017-0745-2
From hybridomas to a robust microalgal-based production platform: molecular design of a diatom secreting monoclonal antibodies directed against the Marburg virus nucleoprotein
Hempel F, Maurer M, Brockmann B, Mayer C, Biedenkopf N, Kelterbaum A, Becker S, Maier UG

J. Gen. Virol., 2017 Jul 4, doi: 10.1099/jgv.0.000879
Identification and characterization of a Golgi retention signal in feline coronavirus accessory protein 7b
Dominik Florek, Rosina Ehmann, Claudia Kristen-Burmann, Tanja Lemmermeyer, Günter Lochnit, John Ziebuhr, Heinz-Jürgen Thiel and Gergely Tekes

J. Virol., 2017 Mar 29, doi: 10.1128/JVI.00246-17
pH optimum of hemagglutinin-mediated membrane fusion determines sensitivity of influenza A viruses to the interferon-induced antiviral state and IFITMs
Thomas Gerlach, Luca Hensen, Tatyana Matrosovich, Janina Bergmann, Michael Winkler, Christin Peteranderl, Hans-Dieter Klenk, Friedemann Weber, Susanne Herold, Stefan Pöhlmann, Mikhail Matrosovich

PLOS Pathogens, 2017 Mar 29; doi: 10.1371/journal.ppat.1006286
The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells
Michael Poppe, Sascha Wittig, Liane Jurida, Marek Bartkuhn, Jochen Wilhelm, Helmut Müller, Knut Beuerlein, Nadja Karl, Sabin Bhuju, John Ziebuhr, M. Lienhard Schmitz, Michael Kracht

J. Public Health Emerg., 2017 Jan 17; doi: 10.21037/jphe.2016.12.16
Persistence of Ebola virus in the semen of male survivors
Roland K. Hartmann, Arnold Grünweller, Thomas Strecker


2016

J. Antivir. Antiretrovir., 2016 Dec 30; doi: 10.4172/jaa.1000151
D, L-lysine aceylsalicylate + glycine Impairs Coronavirus Replication
Christin Müller, Nadja Karl, John Ziebuhr and Stephan Pleschka

J. Gen. Virol., 2016 Dec 23; doi: 10.1099/jgv.0.000697
Cooperative enhancement of translation by two adjacent microRNA-122/Argonaute 2 complexes binding to the 5' untraslated region of Hepatitis C Virus RNA
Anika Nieder-Röhrmann, Nadia Dünnes, Gesche K. Gerresheim, Lyudmila A. Shalamova, Andreas Herchenröther, Michael Niepmann

J. Antivir. Antiretrovir., 2016 Dec 15; doi: 10.4172/1948-5964.1000147
Verapamil has antiviral activities that target different steps of the influenza virus replication cycle
Mohammad Intakhab Alam, Ahmed Mostafa, Pumaree Kanrai, Christin Müller, Julia Dzieciolowski, Eva Lenz, Irina Kuznetsova, Patricia Schult-Dietrich, John Ziebuhr, Ursula Dietrich, and Stephan Pleschka

J. Antiviral., 2016 Nov 15; doi: 10.1016/j.antiviral.2016.11.011
The natural compound silvestrol is a potent inhibitor of Ebola virus replication
Nadine Biedenkopf, Kerstin Lange-Grünweller, Falk W. Schulte, Aileen Weißer, Christian Müller, Dirk Becker, Stephan Becker, Roland K. Hartmann, Arnold Grünweller

J. Virol., 2016 Nov 9; doi: 10.1128/JVI.01913-16
Functional Characterization of Adaptive Mutations during the West African Ebola Virus Outbreak
Erik Dietzel, Gordian Schudt, Verena Krähling, Mikhail Matrosovich, and Stephan Becker

J. Gen. Virol., 2016 Oct; doi: 10.1099/jgv.0.000564
An active site mutation increases the polymerase activity of the guinea pig-lethal Marburg virus

Alexander Köhler, Larissa Kolesnikova, Stephan Becker

Curr. Opin. Immunol., 2016 Oct; doi:10.1016/j.coi.2016.05.016
Standing on three legs: antiviral activities of RIG-I against influenza viruses
Michaela Weber-Gerlach, Friedemann Weber

Genome Announc., 2016 Oct 6; doi: 10.1128/genomeA.01011-16
Complete genome sequence of an Ebola virus isolate imported from Sierra Leone to Germany determined by Circle sequencing
Jan Philipp Mengel, Artur Lissin, Nadine Biedenkopf, Tilman Schultze, Gopala Mannala, Gordian Schudt, Gerrit Kann, Timo Wolf, Markus Eickmann, Stephan Becker, Franz Cemic, Torsten Hain

Cell. Mol. Life Sci., 2016 Sep 27; doi: 10.1007/s00018-016-2377-9
microRNA-122 target sites in the hepatitis C virus RNA NS5B coding region and 3' untranslated region: function in replication and influence of RNA secondary structure
Gesche K. Gerresheim, Nadia Dünnes, Anika Nieder-Röhrmann, Lyudmila A. Shalamova, Markus Fricke, Ivo Hofacker, Christian Höner zu Siederdissen, Manja Marz, Michael Niepmann

Genome Announc., 2016 Sep 22; doi: 10.1128/genomeA.00938-16
Genome sequence of Lassa virus isolated from the first domestically acquired case in Germany
Svenja Wolff, Tilman Schultze, Sarah Fehling, Jan Philipp Mengel, Gerrit Kann, Timo Wolf, Markus Eickmann, Stephan Becker, Torsten Hain, and Thomas Strecker

J. Virol., 2016 Jul 20; doi: 10.1128/JVI.00041-16
To conquer the host, Influenza virus is packing it in: interferon-antagonistic strategies beyond NS1
Michaela Weber-Gerlach, Friedeman Weber

J. Allergy Clin. Immunol., 2016 Jul; 138(1):47-56
Current concepts in chronic inflammatory diseases: interactions between microbes, cellular metabolism and inflammation
Garn, H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C , Rook G, Russell S , Schmeck B, Stappenbeck T, Steinhoff U, van Os J, Weiss S, Zemlin M, Renz H.

J. Virol., 2016 Jun 29; doi: 10.1128/JVI.00946-16
The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB
Sharmistha Dam, Michael Kracht, Stephan Pleschka and M. Lienhard Schmitz

PLOS Pathogens, 2016 Jun 20; doi: 10.1371/journal.ppat.1005544
Influenza Virus infects epithelial stem/progenitor cells of the distal lung: impact on Fgfr2b-driven epithelial repair
Quantius J, Schmoldt C, Vazquez-Armendariz AI, Becker C, El Agha E, Wilhelm J, Morty RE, Vadász I, Mayer K, Gattenloehner S, Fink L, Matrosovich M, Li X, Seeger W, Lohmeyer J, Bellusci S, Herold S.

J. Virol., 2016 Jun 8; pii: JVI.00271-16. [Epub ahead of print]
RNA-binding of Ebola virus VP30 is essential for activating viral transcription
Biedenkopf, N., Schlereth, J., Grünweller, A., Becker S., Hartmann, R.H.

RNA Biol., 2016 Jun; 17:0. [Epub ahead of print] PMID: 27315567
RNA binding specificity of Ebola virus transcription factor VP30
Schlereth, J., Grünweller, A., Biedenkopf, N., Becker S., Hartmann, R.K.

J. Virol., 2016 Apr 29; 90(10):4914-25. doi: 10.1128/JVI.03257-15
Dynamic Phosphorylation of VP30 is essential for Ebola virus life cycle
Biedenkopf, N., Lier, C., and Becker, S.

J. Virol., 2016 Apr 27; doi: 10.1128/JVI.00016-16
NSs virulence factor of Rift Valley fever virus engages the F-box proteins FBXW11 and β-TRCP1 to degrade PKR
Kainulainen, M., S. Lau, C.E. Samuel, V. Hornung, F. Weber.

J. Clin. Invest., 2016 Apr 1; 126(4):1566-80
Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection
Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu G, Budinger GRS, Herold S.

Eur. Resp. J., 2016 Mar; 47(3):954-66
Influenza Virus damages the alveolar barrier by disrupting epithelial tight junctions
Short KR, Kasper J, van der Aa S, Andeweg AC, Zaaraoui-Boutahar F, Goeijenbier M, Richard M, Herold S, Becker C, Scott DP, Limpens RWAL, Barcena M, Fouchier RAM, Kirkpatrick CJ, Kuiken T.

Vet. Microbiol., 2016 Feb 29; doi: 10.1016/j.vetmic.2015.12.009
Characterization of monoclonal antibodies against feline coronavirus accessory protein 7b
Tanja Lemmermeyer, Benjamin Lamp, Rainer Schneider, John Ziebuhr, Gergely Tekes, Heinz-Jürgen Thiel

Sci. Rep.
, 2016 Feb 25; doi: 10.1038/srep21977
Spatial and temporal evolution of Lassa virus in the natural host population in Upper Guinea
Elisabeth Fichet-Calvet, Stephan Ölschläger, Thomas Strecker, Lamine Koivogui, Beate Becker-Ziaja, Amara Bongo Camara, Barré Soropogui, N'Faly Magassouba, Stephan Günther

PLOS Pathogens, 2016 Feb 5; doi: 10.1371/journal.ppat.1005418
Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike
Sai Li, Zhaoyang, Rhys Pryce, Marie-Laure Parsy, Sarah K. Fehling, Katrin Schlie, Alistair Siebert, Wolfgang Garten, Thomas A. Bowden, Thomas Strecker, Juha T. Huiskonen

J. Gen. Virol., 2016 Jan 14; doi: 10.1099/jgv.0.000403
The New World Arenavirus Tacaribe induces caspase-dependent apoptosis in infected cells
Svenja Wolff, Allison Groseth, Bjoern Meyer, David Jackson, Thomas Strecker, Andreas Kaufmann, Stephan Becker

Mol. Cell, 2016; 62:943-957
K63-ubiquitylation and TRAF6 pathways regulate mammalian P-body formation and mRNA decapping
Tenekeci, U, Poppe, M, Beuerlein, K, Buro, C, Muller, H, Weiser, H, Kettner-Buhrow, D, Porada, K,  Newel, D,  Xu,  M, Chen, ZJ, Busch, J, Schmitz, ML and Kracht, M.

J. Gen. Virol.2016; doi: 10.1099/jgv.1090.000458. [Epub ahead of print]
Proteolytic processing of mesonivirus replicase polyproteins by the viral 3C-like protease
Blanck S, Ziebuhr J.

J. Gen. Virol.2016; doi: 10.1099/jgv.0.000483. [Epub ahead of print]
Species-specific and individual differences in NiV replication in porcine and human airway epithelial cells
Sauerhering L, Zickler M, Elvert M, Behner L, Matrosovich T, Erbar S, Matrosovich M, Maisner A.

J. Biomol. Screening, 2016; 21:354-62
High-throughput screening using a whole-cell virus replication reporter gene assay to identify inhibitory compounds against Rift Valley fever virus infection
Islam, M.d.K., M. Baudin, J. Eriksson, C. Öberg, M. Habjan, F. Weber, A. K. Överby, C. Ahlm, M. Evander.

Viruses, 2016; 8, 174
Phleboviruses and the Type I Interferon Response
Wuerth, J.D., F. Weber

Arch. Virol., 2016; 161:1505-1515
Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains
Mostafa A, Abdelwhab el-SM, Slanina H, Hussein MA, Kuznetsova I, Schüttler CG, Ziebuhr J, Pleschka S.

J. Gen. Virol., 2016; 97:620-631.
The PB1 segment of an influenza A virus H1N1 2009pdm isolate enhances the replication efficiency of specific influenza vaccine strains in cell culture and embryonated eggs
Mostafa A, Kanrai P, Ziebuhr J, Pleschka S..

Trends Pharmakol. Sci, 2016; 37:101-113
Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression
Schmitz ML, Kracht M.

J. Allergy Clin. Immunol., 2016;137(5): 1302-16
Immune biomarkers in the spectrum of childhood non-communicable diseases
Skevaki CL, van den Berg J, Jones N, Garssen J, Vuillermin P, Levin M, Landay A, Renz H, Calder P, Thornton CA.

J. Allergy Clin. Immunol., 2016;137: 1334-46
Antisense molecules: a new class of drugs
Potaczek D, Garn H, Unger SD, Renz H et al.


2015

J. Virol. 2015 Dec 16; doi: 10.1128/JVI.02920-15
Nipah virus matrix protein influences fusogenicity and is essential for particle infectivity and stability
Erik Dietzel, Larissa Kolesnikova, Bevan Sawatsky, Anja Heiner, Michael Weis, Gary P. Kobinger, Stephan Becker, Veronika von Messling and Andrea Maisner

J. Virol. 2015 Nov 25; doi: 10.1128/JVI.02332-15
H1N1 Swine Influenza Viruses Differ from Avian Precursors by a Higher pH Optimum for Membrane Fusion
Jan Baumann, Nancy Mounogou Kouassi, Emanuela Foni, Hans-Dieter Klenk, Mikhail Matrosovich

J. Virol. 2015 Nov 18; doi: 10.1128/JVI.02670-15
A single Amino Acid Change in the Marburg Virus Matrix Protein VP40 Provides a Replicative Advantage in a Species-Specific Manner

Alexander Köhler, Larissa Kolesnikova, Ulla Welzel, Gordian Schudt, Astrid Herwig and Stephan Becker

Anal. Biochem. 2015 Oct 1; doi: 10.1016/j.ab.2015.06.022
Application of surface plasmon resonance imaging technique for the detection of single spherical biological submicrometer particles
Victoria Shpacovitch, Vladimir Temchura, Mikhail Matrosovich, Joachim Hamacher, Julia Skolnik, Pascal Libuschewski, Dominic Siedhoff, Frank Weichert, Peter Marwedel, Heinrich Müller, Klaus Überla, Roland Hergenröder, Alexander Zybin

J. Virol. 2015 Sep 16; doi: 10.1128/JVI.01292-15
Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus Sjouke Van Poucke, Jennifer Doedt, Jan Baumann, Yu Qui, Tatyana Matrosovich, Hans-Dieter Klenk, Kristien Van Reeth, Mikhail Matrosovich

J. Cyto. 2015 Jul 10; doi: 10.1016/j.cyto.2015.07.002
The catcher in the RIG-1
Friedemann Weber

RNA. 2015 Jul; 21(7):1219-32
Conserved RNA secondary structures and long-range interactions in hepatitis C viruses
Fricke M, Dünnes N, Zayas M, Bartenschlager R, Niepmann M, Marz M.

Biochemistry (Mosc), 2015 Jul; 80(7):872-80
What Adaptive Changes in Hemagglutinin and Neuraminidase Are Necessary for Emergence of Pandemic Influenza Virus from Its Avian Precursor?
A. S. Gambaryan and M. N. Matrosovich

J. Infect Dis. 2015 Jun 2; doi: 10.1093/infdis/jiv083
Transport of Ebolavirus Nucleocapsids Is Dependent on Actin Polymerization: Live-Cell Imaging Analysis of Ebolavirus-Infected Cells
Gordian Schudt, Olga Dolnik, Larissa Kolesnikova, Nadine Biedenkopf, Astrid Herwig and Stephan Becker

Cell Host & Microbe 2015 Mar 11; pii: S1931-3128(15)00025-6
Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I
Michaela Weber, Hana Sediri, Ulrike Felgenhauer, Ina Binzen, Sebastian Bänfer, Ralf Jacob, Linda Brunotte, Adolfo Garcia-Sastre, Jonathan L. Schmid-Burgk, Tobias Schmidt, Veit Hornung, Georg Kochs, Martin Schwemmle, Hans-Dieter Klenk, Friedemann Weber

Cell Host & Microbe 2015 Mar 11; 17:416-416.e411
SnapShot: Evolution of Human Influenza A Viruses
Isabel Wendel, Mikhail Matrosovich, Hans Dieter Klenk

Virus Res. 2015 Feb 25; pii: SO168-1702(15)00096-9
Fusion activity of African heniparvirus F proteins with a naturally occurring start codon directly upstream of the signal peptide
Michael Weis, Laura Behner, Tabea Binger, Jan Felix Drexler, Christian Drosten, Andrea Maisner

J. Virol. 2015 Jan 28; pii: JVI.03194-14, Epub ahead of print
The Avian-Origin PB1 Gene Segment Facilitated Replication and Transmissibility of the H3N2/1968 Pandemic Influenza Virus
Isabel Wendel, Dennis Rubbenstroth, Jennifer Doedt, Georg Kochs, Jochen Wilhelm, Peter Staeheli, Hans-Dieter Klenk, Mikhail Matrosovich

Biochim. Biophys. Acta 2015 Jan; 1853: 136-143
SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity
Vera V. Saul, Rainer Niedenthal, Andreas Pich, Friedemann Weber, M. Lienhard Schmitz

PLoS One 2015; 10:e0120498
A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand
Jung S, von Thülen T, Laukemper V, Pigisch S, Hangel D, Wagner H, Kaufmann A, Bauer S.

J Virol. 2015; 90:2706-2709
Early activation of primary brain microvascular endothelial cells by Nipah virus glycoprotein-containing particles
Freitag TC, Maisner A.

Sci Rep. 2015; 5:11434
In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses
Schmier S, Mostafa A, Haarmann T, Bannert N, Ziebuhr J, Veljkovic V, Dietrich U, Pleschka S.

Nature Rev Dis Primers, doi 10.1038/nrdp.2015.25
Asthma
Holgate ST, Wenzel S, Postma DS, Weiss ST, Renz H, Sly PD.


2014

J. Vis. Exp. 2014; (89), e51415
Monitoring activation of the antiviral pattern recognition rceptors RIG-I and PKR by limited protease digestion and native PAGE
Michaela Weber, Friedemann Weber

Cytokine Growth Factor Rev. 2014 Oct; 25: 621-628
RIG-I-like receptors and negative-strand RNA viruses: RLRly bird catches some worms
Michaela Weber, Friedemann Weber

J. Virol. 2014 Sep 17; doi: 10.1128/JVI 02040-14
Characterization of an alphamesonivirus 3C-like protease defines a special group of nidovirus main proteases
Sandra Blanck, Anne Stinn, Lali Tsiklauri, Florian Zirkel, Sandra Junglen and John Ziebuhr

Current Opinion in Microbiology 2014 Aug; 20: 96-102
Segmented negative-strand RNA viruses and RIG-I: divide (your genome) and rule
Michaela Weber, Friedemann Weber

Vet Microbiol. 2014 Aug 4; pii: S0378-1135(14)00355-1
Mutations of 3c and spike protein genes correlate with the occurrence of feline infectious peritonitis
Bank-Wolf BR, Stallkamp I, Wiese S, Moritz A, Tekes G, Thiel HJ

Bioengineered 2014 Jul 24; 5(6)
Tackling feline infectious peritonitis via reverse genetics
Thiel V, Thiel HJ., Tekes G

Curr Top Microbiol Immunol 2014 Jul 17; 385:3-34
The hemagglutinin: a determinant of pathogenicity
Böttcher-Friebertshäuser E, Garten W, Matrosovich M, Klenk HD

Nucl. Acids Res. 2014 May 14; 42: 6025-6037
Structural insights into RNA encapsdation and helical assembly of the Toscana virus nucleoprotein
Daniel Olal, Alexej Dick, Virgil L. Woods Jr, Tong Liu, Sheng Li, Stéphanie Devignot, Friedemann Weber, Erica Ollmann Saphire, Oliver Daumke

J. Virol. 2014 Mar; 88: 6 3464-3473
Virulence Factor NSs of Rift Valley Fever Virus Recruits the F-Box Protein FBXO3 To Degrade Subunit p62 of General Transcription Factor TFIIH
Markus Kainulainen, Matthias Habjan, Philipp Hubel, Laura Busch, Simone Lau, Jacques Colinge, Giulio Superti-Furga, Andreas Pichlmair and Friedemann Weber

Virus Res. 2014; 194:76-89
RNA structure analysis of alphacoronavirus terminal genome regions
Madhugiri R, Fricke M, Marz M, Ziebuhr J.

Arch Virol. 2014 May; 159(5):849-62. Review
The role of microRNAs in hepatitis C virus RNA replication
Conrad KD, Niepmann M.

J Gen Virol. 2014; 95:539-548.
Characterization of African bat henipavirus GH-M74a glycoproteins
Weis M, Behner L, Hoffmann M, Krüger N, Herrler G, Drosten C, Drexler JF, Dietzel E, Maisner A.

Biochim. Biophys. Acta, 2014; 1843:2754-2764.
The intricate interplay between RNA viruses and NF-κB. Biochim
Schmitz ML, Kracht M, Saul VV.


2013

Top Curr Chem 2013 Jul 20; 20:20
Sialic Acid Receptors of Viruses
Mikhail Matrosovich, Georg Herrler, Hans Dieter Klenk

J. Virol. 2013 Jul; 87(14): 8205-12. doi: 10.1128/JVI.00371-13. Epub 2013 May 22.
Systems to establish bunyavirus genome replication in the absence of transcription
Klemm C, Reguera J, Cusack S, Zielecki F, Kochs G, Weber F.

PLoS One 2013;8(2):e56272.
MicroRNA-122 dependent binding of Ago2 protein to hepatitis C virus RNA is associated with enhanced RNA stability and translation stimulation
Conrad KD, Giering F, Erfurth C, Neumann A, Fehr C, Meister G, Niepmann M.

Curr Top Microbiol Immunol. 2013; 369:143-66. Review
Hepatitis C virus RNA translation
Niepmann M.